Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin

The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammoni...

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Autor principal: Rodriguez, M.E
Otros Autores: Fernández, D.A, Awruch, J., Braslavsky, Silvia Elsa, Dicelio, L.E
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Society of Porphyrins and Phthalocyanines (SPP) 2006
Acceso en línea:Registro en Scopus
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100 1 |a Rodriguez, M.E. 
245 1 0 |a Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin 
260 |b Society of Porphyrins and Phthalocyanines (SPP)  |c 2006 
270 1 0 |m Dicelio, L.E.; INQUIMAE, Departamento de Química Inorgánica, Analítica Y Química Física, Ciudad Universitaria, 1428 Buenos Aires, Argentina; email: led@q1.fcen.uba.ar 
504 |a MacDonald, I.J., Dougherty, T.J., (2001) J. Porphyrins Phthalocyanines, 5, pp. 105-129 
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504 |a Konan, Y.N., Gurny, R., Allémann, E., (2002) J. Photochem. Photobiol. B, 66, pp. 89-106 
504 |a Fernández, D.A., Awruch, J., Dicelio, L.E., (1997) J. Photochem. Photobiol. B, 41, pp. 227-232 
504 |a Lagorio, M.G., Dicelio, L.E., San Román, E., (1993) J. Photochem. Photobiol. A, 72, pp. 153-161 
504 |a Fernández, D.A., Awruch, J., Dicelio, L.E., (1996) Photochem. Photobiol., 63, pp. 784-792 
504 |a Laroque, C., Pelegrin, A., Van Lier, J.E., (1996) Br. J. Cancer., 74, pp. 1886-1890 
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504 |a Chirvony, V.S., (2003) J. Porphyrins Phthalocyanines, 7, pp. 766-774 
504 |a Shai, E., Fernández, D.A., Gross, S., Dicelio, L.E., Scherz, A., Salomon, Y., Awruch, J., (1999) ELAFOT VI, pp. P-11. , Brasil 
504 |a Fernández, D.A., Dicelio, L.E., Awruch, J., (1995) J. Heterocyclic Chem., 32, pp. 519-522 
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504 |a Rodriguez, M.E., Awruch, J., Dicelio, L.E., (2002) J. Porphyrins Phthalocyanines, 6, pp. 122-129 
504 |a Daraio, M.E., Aramendía, P.F., San Román, E.A., Braslavsky, S.E., (1991) Photochem. Photobiol., 54, pp. 367-373 
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506 |2 openaire  |e Política editorial 
520 3 |a The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammonium chloride (CTAC). Spectrophotometric measurements showed that the surfactants SDS and CTAC induce monomerization of I, although the latter less efficiently than the former. This effect is less pronounced in the presence of HSA. The strength of this effect is evaluated through dimerization constants, which are K d = (5 ± 1) × 105 M-1 in SDS, (1.5 ± 0.5) × 106 M-1 in CTAC, and (1.8 ± 0.9) × 106 M-1 in HSA. Fluorescence experiments confirm that aggregation of I drops as the concentration of surfactant is raised. Triplet quantum yields also decreased upon aggregation and were ΦT = 0.59, 0.16, and < 0.01 in SDS, CTAC, and HSA, respectively. These results indicate that the affinity of I for the environment is not just due to ionic interactions; hydrophobic interactions play an equally important role. Copyright © 2006 Society of Porphyrins & Phthalocyanines.  |l eng 
593 |a INQUIMAE, Departamento de Química Inorgánica, Analítica Y Química Física, Ciudad Universitaria, 1428 Buenos Aires, Argentina 
593 |a Departamento de Química Orgánica, Facultad de Farmacia Y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina 
593 |a Max-Planck-Institut für Bioanorganische Chemie (Formerly Strahlenchemie), Postfach 10 13 65, D-45413 Mülheim an der Ruhr, Germany 
593 |a Tyrolit Argentina S.A. Boquerón 741-(B1708CRE), Morón, Argentina 
690 1 0 |a AGGREGATION 
690 1 0 |a ALBUMIN 
690 1 0 |a HYDROPHOBIC INTERACTIONS 
690 1 0 |a MICELLES 
690 1 0 |a TETRAKIS(1,1- DIMETHYL-2-TRIMETHYLAMMONIUM)ETHYLPHTHALOCYANINATO ZINC(II) TETRAIODIDE 
700 1 |a Fernández, D.A. 
700 1 |a Awruch, J. 
700 1 |a Braslavsky, Silvia Elsa 
700 1 |a Dicelio, L.E. 
773 0 |d Society of Porphyrins and Phthalocyanines (SPP), 2006  |g v. 10  |h pp. 33-42  |k n. 1  |p J. Porphyrins Phthalocyanines  |x 10884246  |t Journal of Porphyrins and Phthalocyanines 
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856 4 0 |u https://doi.org/10.1142/S1088424606000053  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_10884246_v10_n1_p33_Rodriguez  |y Handle 
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