A polar mechanism coordinates different regions of alternative splicing within a single gene

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Alternative splicing plays a key role in generating protein diversity. Transfections with minigenes revealed coordination between two distant, alternatively spliced exons in the same gene. Mutations that either inhibit or stimulate inclusion of the upstream alternative exon deeply affect inclusion o...

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Detalles Bibliográficos
Autores principales: Fededa, J.P., Petrillo, E., Gelfand, M.S., Neverov, A.D., Kadener, S., Nogués, G., Pelisch, F., Baralle, F.E., Muro, A.F., Kornblihtt, A.R.
Formato: Artículo publishedVersion
Publicado: 2005
Materias:
fibronectin
alternative RNA splicing
article
bioinformatics
cis isomer
gene identification
human
nonhuman
transcription regulation
Alleles
Alpha-Globulins
Alternative Splicing
Animals
Antigens, Viral, Tumor
Cell Line, Tumor
Cercopithecus aethiops
Computational Biology
COS Cells
Dichlororibofuranosylbenzimidazole
DNA-Binding Proteins
Exons
Fibroblasts
Fibronectins
Genes
Humans
Mice
Mice, Knockout
Models, Genetic
Nuclear Proteins
Promoter Regions (Genetics)
Protein Isoforms
RNA Polymerase II
RNA Splicing
RNA-Binding Proteins
Transcription Factors
Transfection
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10972765_v19_n3_p393_Fededa
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_10972765_v19_n3_p393_Fededa_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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