The Critical Role of Intrinsic Membrane Oscillations

Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These o...

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Detalles Bibliográficos
Publicado: 2018
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1424862X_v_n_p66_Lee
http://hdl.handle.net/20.500.12110/paper_1424862X_v_n_p66_Lee
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_1424862X_v_n_p66_Lee
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spelling paper:paper_1424862X_v_n_p66_Lee2023-06-08T16:14:03Z The Critical Role of Intrinsic Membrane Oscillations Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on continuous gamma band activity are subserved by subthreshold oscillations. As such, intrinsic oscillations, coupled with synaptic circuits, are essential to prolonged maintenance of such functions as sensory perception and "binding", problem solving, memory, waking, and rapid eye movement (REM) sleep. © 2018 The Author(s). Published by S. Karger AG, Basel. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1424862X_v_n_p66_Lee http://hdl.handle.net/20.500.12110/paper_1424862X_v_n_p66_Lee
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on continuous gamma band activity are subserved by subthreshold oscillations. As such, intrinsic oscillations, coupled with synaptic circuits, are essential to prolonged maintenance of such functions as sensory perception and "binding", problem solving, memory, waking, and rapid eye movement (REM) sleep. © 2018 The Author(s). Published by S. Karger AG, Basel.
title The Critical Role of Intrinsic Membrane Oscillations
spellingShingle The Critical Role of Intrinsic Membrane Oscillations
title_short The Critical Role of Intrinsic Membrane Oscillations
title_full The Critical Role of Intrinsic Membrane Oscillations
title_fullStr The Critical Role of Intrinsic Membrane Oscillations
title_full_unstemmed The Critical Role of Intrinsic Membrane Oscillations
title_sort critical role of intrinsic membrane oscillations
publishDate 2018
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1424862X_v_n_p66_Lee
http://hdl.handle.net/20.500.12110/paper_1424862X_v_n_p66_Lee
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