Simulación numérica del crecimiento de un tumor avascular
A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient...
| Publicado: |
2016
|
|---|---|
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97814673_v_n_p_Weiman http://hdl.handle.net/20.500.12110/paper_97814673_v_n_p_Weiman |
| Aporte de: |
| Sumario: | A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient concentration and a delay factor to the main equations of the model due to the release of cytostatic and cytotoxic factors from the necrotic core of the tumor. Lastly, we proposed a new delay model that led to a more suitable representation of the physiopathological phenomena in so far as the simulation shows the deceleration in the tumor growth and the decrease of proliferative cell density over time, as a consequence of the presence of the aforementioned cytostatic and cytotoxic factors. © 2016 IEEE. |
|---|