Differences in nuclear retention characteristics of agonist-activated glucocorticoid receptor may determine specific responses

We studied the glucocorticoid response to the synthetic steroid pregna-1,4-diene-11β-ol-3,20-dione (ΔHOP) in several cell types and correlated its biological effect with the ability of the glucocorticoid receptor (GR) to be retained in the nuclear compartment. We observed that the ΔHOP-transformed G...

Descripción completa

Detalles Bibliográficos
Autores principales: Vicent, G.P., Pecci, A., Ghini, A., Piwien-Pilipuk, G., Galigniana, M.D.
Formato: JOUR
Materias:
adenosine triphosphate
dexamethasone
digitonin
glucocorticoid receptor
mifepristone
molybdic acid
pregna 1,4 11beta ol 3,20 dione
steroid
unclassified drug
animal cell
animal tissue
apoptosis
article
cell membrane permeability
cell permeabilization
chromatin
conformation
controlled study
cytolysis
dose response
drug effect
ligand binding
male
mouse
nonhuman
pleiotropy
priority journal
protein degradation
rat
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00144827_v276_n2_p142_Vicent
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares