AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication

We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones. Combined knock down of chaperones or AR-12 treatment acted to reduce the expression of virus receptors and essential glucosidase proteins. Combined knock dow...

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Detalles Bibliográficos
Autores principales: Booth, L., Roberts, J.L., Ecroyd, H., Tritsch, S.R., Bavari, S., Reid, S.P., Proniuk, S., Zukiwski, A., Jacob, A., Sepúlveda, C.S., Giovannoni, F., García, C.C., Damonte, E., González-Gallego, J., Tuñón, M.J., Dent, P.
Formato: JOUR
Materias:
2 amino n [4 [5 (2 phenanthrenyl) 3 trifluoromethyl 1h pyrazol 1 yl]phenyl]acetamide
adenosine triphosphatase
antivirus agent
ar 12
beclin 1
chaperone
gamma glutamyltransferase
glucose regulated protein 78
glucosidase
heat shock protein 27
heat shock protein 70
heat shock protein 90
initiation factor 2alpha
lactate dehydrogenase
lc3 protein
mammalian target of rapamycin
pazopanib
small interfering RNA
sorafenib
unclassified drug
virus protein
virus receptor
animal experiment
Article
autophagosome
autophagy
cell killing
cell viability
controlled study
Coxsackievirus B4
cytolysis
Ebolavirus
endoplasmic reticulum stress
enzyme release
experimental rabbit
gene overexpression
gene silencing
human
human cell
Human immunodeficiency virus
immunofluorescence test
Influenza virus
Junin virus
macrophage
Measles virus
mouse
Mumps virus
nonhuman
priority journal
protein dephosphorylation
protein glycosylation
protein localization
protein phosphorylation
protein protein interaction
Rubella virus
virus replication
wild type
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219541_v231_n10_p2286_Booth
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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