Conformational Analysis of Novel Monoaryl Substituted Protoporphyrins by 1D NOE, 2D NOESY and Molecular Modeling Studies

Porphyrins 1-4 are monoaryl protoporphyrins substituted on C-5 or C-15 by a phenyl group. One- and two-dimensional nOe experiments and molecular modeling studies allowed us to find the most favorable conformations for these compounds. In the four porphyrins, the exocyclic phenyl group adopts a non-c...

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Detalles Bibliográficos
Autores principales: Robinsohn, A.E., Buldain, G.Y., Maier, M.S.
Formato: JOUR
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0022152X_v34_n4_p1339_Robinsohn
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Sumario:Porphyrins 1-4 are monoaryl protoporphyrins substituted on C-5 or C-15 by a phenyl group. One- and two-dimensional nOe experiments and molecular modeling studies allowed us to find the most favorable conformations for these compounds. In the four porphyrins, the exocyclic phenyl group adopts a non-coplanar disposition relative to the plane of the macrocycle and this is reflected in the 1D nOe difference and 2D NOESY results. In porphyrins 1 and 3 the macrocycle is nearly planar while nonplanar saddle conformations were obtained for porphyrins 2 and 4.