21-hydroxy-6,19-oxidoprogesterone: A novel synthetic steroid with specific antiglucocorticoid properties in the rat

In the rat, the conformationally highly befit steroid 21-hydroxy-6,19- oxidoprogesterone efficiently displaces [3H]corticostetone from thymus- glucocorticoid receptors and blocks type II receptors in kidney cytosols but competes with neither [3H]aldosterona for kidney-mineralocorticoid receptors nor...

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Detalles Bibliográficos
Autores principales:	Vicent, G.P., Monteserín, M.C., Veleiro, A.S., Burton, G., Lantos, C.P., Galigniana, M.D.
Formato:	JOUR
Materias:	11beta,17beta dihydroxy 6 methyl 17alpha (1 propynyl)androsta 1,4,6 trien 3 one 15beta,16beta methylenemexrenone 21 hydroxy 6,19 oxidoprogesterone aldosterone corticosterone dexamethasone glucocorticoid antagonist glucocorticoid receptor mineralocorticoid receptor progesterone steroid tyrosine aminotransferase unclassified drug animal tissue article controlled study cytosol dose response drug conformation drug receptor binding enzyme induction kidney cell male nonhuman priority journal rat sodium retention
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0026895X_v52_n4_p749_Vicent
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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