High molecular weight components containing N-linked oligosaccharides of Ascaris suum extract inhibit the dendritic cells activation through DC-SIGN and MR

Helminths, as well as their secretory/excretory products, induce a tolerogenic immune microenvironment. High molecular weight components (PI) from Ascaris suum extract down-modulate the immune response against ovalbumin (OVA). The PI exerts direct effect on dendritic cells (DCs) independent of TLR 2...

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Detalles Bibliográficos
Autores principales:	Favoretto, B.C., Casabuono, A.A.C., Portes-Junior, J.A., Jacysyn, J.F., Couto, A.S., Faquim-Mauro, E.L.
Formato:	JOUR
Materias:	Ascaris suum C-type lectin receptors DC-Dendritic Cell DCSIGN-Dendritic cell specifc ICAM-3 grabbing non-integrin MR-Mannose receptor PI - High molecular weight components from Ascaris suum extract asparagine linked oligosaccharide CD209 antigen Freund adjuvant granulocyte macrophage colony stimulating factor high molecular weight component interleukin 4 mannan mannose receptor natural products and their synthetic derivatives ovalbumin unclassified drug lectin oligosaccharide phosphorylcholine animal cell animal experiment Article binding affinity binding assay bound fraction Canavalia ensiformis cell activation cell surface cell suspension confocal microscopy dendritic cell flow cytometry immunization in vitro study internalization lectin binding lymphocyte proliferation male matrix assisted laser desorption ionization time of flight mass spectrometry molecular weight mouse nonhuman priority journal protein content purification retention time T lymphocyte animal Bagg albino mouse cell proliferation chemistry drug effects immunology lymphocyte activation Animals Cell Proliferation Dendritic Cells Lectins, C-Type Lymphocyte Activation Male Mannans Mice Mice, Inbred BALB C Molecular Weight Oligosaccharides Ovalbumin Phosphorylcholine T-Lymphocytes
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01615890_v87_n_p33_Favoretto
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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