PKMζ inactivation induces spatial familiarity

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Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated...

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Detalles Bibliográficos
Autores principales: Moncada, D., Viola, H.
Formato: JOUR
Materias:
protein inhibitor
protein kinase
protein kinase m zeta
unclassified drug
zeta interacting protein
enzyme inhibitor
peptide
protein kinase C
protein kinase M zeta, rat
animal experiment
animal tissue
article
controlled study
exploratory behavior
hippocampus
histology
immunoblotting
male
nonhuman
open field test
priority journal
rat
spatial discrimination
analysis of variance
animal
behavior
drug effect
gene expression regulation
metabolism
physiology
recognition
time
Wistar rat
Analysis of Variance
Animals
Enzyme Inhibitors
Exploratory Behavior
Gene Expression Regulation
Hippocampus
Male
Peptides
Protein Kinase C
Rats
Rats, Wistar
Recognition (Psychology)
Spatial Behavior
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place. © 2008 Cold Spring Harbor Laboratory Press.

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