pH-Dependent Conformational Changes in Proteins and Their Effect on Experimental pKas: The Case of Nitrophorin 4

The acid-base behavior of amino acids is an important subject of study due to their prominent role in enzyme catalysis, substrate binding and protein structure. Due to interactions with the protein environment, their pKas can be shifted from their solution values and, if a protein has two stable con...

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Detalles Bibliográficos
Autores principales: Di Russo, N.V., Estrin, D.A., Martí, M.A., Roitberg, A.E.
Formato: JOUR
Materias:
aspartic acid
carrier protein
nitrophorin 4
unclassified drug
article
conformational transition
molecular dynamics
molecular model
pH
pKa
protein analysis
protein conformation
protein interaction
structure analysis
Animals
Aspartic Acid
Computational Biology
Computer Simulation
Hemeproteins
Hydrogen-Ion Concentration
Insect Proteins
Models, Chemical
Models, Molecular
Protein Conformation
Protein Folding
Rhodnius
Salivary Proteins and Peptides
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1553734X_v8_n11_p_DiRusso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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