Anti-hemagglutinin antibody derived lead peptides for inhibitors of influenza virus binding

Antibodies against spike proteins of influenza are used as a tool for characterization of viruses and therapeutic approaches. However, development, production and quality control of antibodies is expensive and time consuming. To circumvent these difficulties, three peptides were derived from complem...

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Detalles Bibliográficos
Autores principales: Memczak, H., Lauster, D., Kar, P., Lella, S.D., Volkmer, R., Knecht, V., Herrmann, A., Ehrentreich-Förster, E., Bier, F.F., Stöcklein, W.F.M.
Formato: JOUR
Materias:
antivirus agent
Influenza virus hemagglutinin antibody derivative
peptide PeA
peptide PeB
peptide PeC
unclassified drug
virus spike protein
epitope
Influenza virus hemagglutinin
neutralizing antibody
virus antibody
amino acid substitution
animal cell
antiviral activity
Article
binding affinity
binding competition
circular dichroism
complementarity determining region
concentration response
controlled study
drug binding site
drug design
drug synthesis
genetic procedures
hemagglutination inhibition test
human
human cell
Influenza A virus
Influenza A virus (A/Aichi/2/68(H3N2))
Influenza A virus (A/California/7/2009(H1N1))
Influenza A virus (A/Mute Swan/Rostock/R901/2006(H7N1))
inhibition kinetics
microarray analysis
molecular dynamics
nonhuman
protein modification
surface plasmon resonance
target cell
virus cell interaction
virus neutralization
virus strain
animal
cell line
dog
immunology
influenza
virology
virus attachment
Animals
Antibodies, Neutralizing
Antibodies, Viral
Cell Line
Dogs
Epitopes
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza, Human
Molecular Dynamics Simulation
Virus Attachment
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v11_n7_p_Memczak
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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