enzyme binding article 22 nonhuman 22 priority journal 18 Animals 14 Binding Sites 12 enzyme activity 12 unclassified drug 12 Models, Molecular 10 Protein Binding 10 catalysis 10 Kinetics 8 Rats 8 amino acid sequence 8 controlled study 8 enzyme active site 8 enzyme mechanism 8 structure activity relation 8 Humans 6 Phosphorylation 6 Protein Conformation 6 Trypanosoma cruzi 6 binding site 6 carboxy terminal sequence 6 chemistry 6 metabolism 6 molecular dynamics 6 molecular interaction 6 molecular model 6 pH 6