hyperinsulinemia nonhuman 6 Animals 4 Hypothalamus 4 Mice 4 Mice, Knockout 4 Obesity 4 Pro-Opiomelanocortin 4 animal cell 4 animal experiment 4 animal model 4 controlled study 4 female 4 hyperglycemia 4 hypothalamus 4 insulin 4 insulin resistance 4 male 4 mouse 4 obesity 4 priority journal 4 proopiomelanocortin 4 Adipose Tissue 2 Adiposity 2 Agouti-Related Protein 2 Arcuate Nucleus of Hypothalamus 2 Article 2 Blood Glucose 2 Blotting, Western 2 Disease Models, Animal 2