Genomic differentiation between Asturiana de los Valles, Avileña - Negra Ibérica, Bruna dels Pirineus, Morucha, Pirenaica, Retinta and Rubia Gallega cattle breeds
The Spanish local beef cattle breeds have most likely common origin followed by a process of differentiation. This particular historical evolution has most probably left detectable signatures in the genome. The objective of this study was to identify genomic regions associated with differentiation p...
| Otros Autores: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Materias: | |
| Acceso en línea: | http://ri.agro.uba.ar/files/intranet/articulo/2017gonzalezRodriguez.pdf LINK AL EDITOR |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
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| 008 | 190426t2017 xxk|||||o|||| 00| | eng d | ||
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| 022 | |a 1751-732X | ||
| 024 | |a 10.1017/S1751731117000398 | ||
| 040 | |a AR-BaUFA |c AR-BaUFA | ||
| 245 | 1 | |a Genomic differentiation between Asturiana de los Valles, Avileña - Negra Ibérica, Bruna dels Pirineus, Morucha, Pirenaica, Retinta and Rubia Gallega cattle breeds | |
| 520 | |a The Spanish local beef cattle breeds have most likely common origin followed by a process of differentiation. This particular historical evolution has most probably left detectable signatures in the genome. The objective of this study was to identify genomic regions associated with differentiation processes in seven Spanish autochthonous populations (Asturiana de los Valles (AV), Avileña-Negra Ibérica (ANI), Bruna dels Pirineus (BP), Morucha (Mo), Pirenaica (Pi), Retinta (Re) and Rubia Gallega (RG)). The BovineHD 777K BeadChip was used on 342 individuals (AV, n = 50; ANI, n=48; BP, n=50; Mo, n=50; Pi, n=48; Re, n=48; RG, n=48) chosen to be as unrelated as possible. We calculated the fixation index ( FST) and performed a Bayesian analysis named SelEstim. The output of both procedures was very similar, although the Bayesian analysis provided a richer inference and allowed us to calculate significance thresholds by generating a pseudo-observed data set from the estimated posterior distributions. We identified a very large number of genomic regions, but when a very restrictive significance threshold was applied these regions were reduced to only 10. Among them, four regions can be highlighted because they comprised a large number of single nucleotide polymorphisms and showed extremely high signals (Kullback Leiber divergence (KLD) greater than 6). They are located in BTA 2 (5 575 950 to 10 152 228 base pairs (bp)), BTA 5 (17 596 734 to 18 850 702 bp), BTA 6 (37 853 912 to 39 441 548 bp) and BTA 18 (13 345 515 to 15 243 838 bp) and harbor, among others, the MSTN (Myostatin), KIT-LG (KIT Ligand), LAP3 (leucine aminopeptidase 3), NAPCG (non-SMC condensing I complex, subunit G), LCORL (ligand dependent nuclear receptor corepressor-like) and MC1R (Melanocortin 1 receptor) genes. Knowledge on these genomic regions allows to identify potential targets of recent selection and helps to define potential candidate genes associated with traits of interest, such as coat color, muscle development, fertility, growth, carcass and immunological response. | ||
| 650 | |2 Agrovoc |9 26 | ||
| 653 | |a BOS TAURUS | ||
| 653 | |a BEEF | ||
| 653 | |a SELECTION | ||
| 653 | |a DIFFERENTIATION | ||
| 653 | |a BAYESIAN ANALYSIS | ||
| 700 | 1 | |a González Rodríguez, Aldemar |u Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética. Zaragoza, Spain. |9 67266 | |
| 700 | 1 | |9 13019 |a Munilla Leguizamón, Sebastián |u Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética. Zaragoza, Spain. |u Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal. Buenos Aires. Argentina. | |
| 700 | 1 | |a Mouresan, Elena Flavia |u Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética. Zaragoza, Spain. |9 70795 | |
| 700 | 1 | |a Cañas Alvarez, J. J. |u Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments. Grup de Recerca en Remugants. Barcelona, Spain. |9 67766 | |
| 700 | 1 | |a Baro, Jesus A. |u Universidad de Valladolid. Departamento de Ciencias Agroforestales. Palencia, Spain. |9 67524 | |
| 700 | 1 | |a Molina, A. |u Universidad de Córdoba. MERAGEM. Córdoba, Spain. |9 44604 | |
| 700 | 1 | |a Díaz, C. |u Departamento de Mejora Genética Animal (INIA). Madrid, Spain. |9 67523 | |
| 700 | 1 | |a Altarriba, Juan |u Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética. Zaragoza, Spain. |u Instituto Agroalimentario de Aragón. Zaragoza, Spain. |9 70314 | |
| 700 | 1 | |a Piedrafita, J. |u Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments. Grup de Recerca en Remugants. Barcelona, Spain. |9 67525 | |
| 700 | 1 | |a Varona, Luis |u Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética. Zaragoza, Spain. |u Instituto Agroalimentario de Aragón. Zaragoza, Spain. |9 67267 | |
| 773 | |t Animal |g vol.11, no.10 (2017), p.1667–1679, grafs., tbls. | ||
| 856 | |f 2017gonzalezRodriguez |i en reservorio |q application/pdf |u http://ri.agro.uba.ar/files/intranet/articulo/2017gonzalezRodriguez.pdf |x ARTI201904 | ||
| 856 | |z LINK AL EDITOR |u https://www.cambridge.org | ||
| 942 | |c ARTICULO | ||
| 942 | |c ENLINEA | ||
| 976 | |a AAG | ||