Immunological and virological markers for the diagnosis of human parvovirus B19 infection during pregnancy
Abstract: Parvovirus B19 (B19V) is a human pathogen prevalent worldwide, responsible for various diseases. If the primary infection occurs during pregnancy, it can cause placental and/or fetal pathologies (including anemia, congestive heart failure, hydrops and fetal death). The diagnosis...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Artículo revista |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35025 |
| Aporte de: |
| Sumario: | Abstract:
Parvovirus B19 (B19V) is a human pathogen prevalent worldwide, responsible for various diseases. If the primary infection occurs during pregnancy, it can cause placental and/or fetal pathologies (including anemia, congestive heart failure, hydrops and fetal death). The diagnosis in these cases is not standardized and there are limitations related to costs, type and timing of clinical samples, as well as laboratory techniques applied in each situation. Therefore, the aim of this study was to characterize the presence of B19V in suspected cases of congenital infection, determining specific immunological and virological markers useful for diagnosis.
Retrospective, observational, analytical and cross-sectional design. Serum samples from pregnant women with maternal or fetal-neonatal clinical manifestations related to B19V infection stored in the biobank of the Clínica Universitaria Reina Fabiola (CURF) were selected according to the digital medical record (Jan 2018-Mar 2021). Infection was determined by viral DNA detection and serology. Protocol approved by the Institutional Committee of Ethics in Health Research of the CURF.
Sixty-five samples were included (63 from pregnant women and 2 from newborns). We confirmed recent or ongoing acute infection in 8/65 (12.3%), all in pregnant women (8/63, 12.7%). Of these, 3/8 were IgM-positive, 5/8 DNA-positive (none with both markers) and 6/8 IgG-positive. A co-detection for the TORCH panel (Herpes simplex-2 IgM) was detected in only one patient. The clinical manifestations included: abortions 6/8(75%), fetal hydrops 3/8(37.5%), maternal anemia 2/8(25%), fetal cardiac alterations 2/8(25%), fetal anemia 1/8(12.5%), hepatosplenomegaly 1/8(12.5%), and polyhydramnios 1/8(12.5%). Of the abortions, 2/6(33.3%) were recurrent, 1/6(16.7%) developed hydrops, 1/6(16.7%) anemia and 1/6(16.7%) fetal heart abnormalities. One pregnant woman presented a rash in the arms (sign of infection).
In conclusion, a high frequency of B19V is reported. B19V infection can be asymptomatic or present nonspecific manifestations during pregnancy, thus early suspicion/detection with a broad case definition is important. Determination of all specific markers is necessary for the diagnosis. |
|---|