Seroprevalence of specific antibodies for rubella, measles and varicella-zoster viruses in pregnant women of a private medical center of Córdoba city, Argentina
Abstract: Rubella, measles, and varicella-zoster can produce exanthematous infections in pregnant women, associated to greater risk or complications, including miscarriage, premature labor, neonatal diseases, and low birth-weight, among others. However, these infections are preventabl...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35030 |
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| Sumario: | Abstract:
Rubella, measles, and varicella-zoster can produce exanthematous infections in pregnant women, associated to greater risk or complications, including miscarriage, premature labor, neonatal diseases, and low birth-weight, among others. However, these infections are preventable by means of existing safe and effective vaccines.
We intended to determine the prevalence of specific antibodies for rubella, measles and varicella-zoster viruses in a population of pregnant women who attended a private medical center in Córdoba city (Argentina).
Retrospective observational study of 826 serum samples from pregnant women aged 18-42 years, collected at the Virology Laboratory Clínica Universitaria Reina Fabiola, from January 1 to December 31, 2020. The population was divided into 5 groups according to age (1 group every 5 years). For determination of antibodies, we used automated Elisa assay (bioMérieux) according to the manufacturer´s instructions. Positive values were defined according to the cut-off points established by the manufacturer for each assay: rubella IgG: ≥15 UI/ml, measles IgG index: ≥0.7 and varicella-zoster IgG index: ≥0.90. The proportion of individuals with immunity against the viruses was compared using Chi square test with 95% CI (p<0.05).
Detected prevalence values were rubella IgG: 95.52%, measles IgG: 79.97%, and varicella-zoster IgG: 94.39%. When comparing the global prevalence of rubella and varicella-zoster with respect to global prevalence of measles (p <0.0001), we observed a higher prevalence of anti-rubella and anti-varicella-zoster antibodies in pregnant women and a significantly lower prevalence against measles virus (global susceptibility: 20.03%).
For this reason, it would be advisable to perform serological control of rubella, measles and varicella before conception in order to establish a new preventive strategy to reduce the risk of these infections in newborns and pregnant women of our community.
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