Creatine phosphokinase enzyme elevation in two third-level hospitals of Córdoba: Creatine phosphokinase enzyme elevation

Introduction: HyperCKemia  is defined as the elevation of creatine phosphokinase (CK) levels greater than 1.5 times the upper limit (CK>285 U/L), being produced by multiple causes, which vary according different populations. The main objective of the study was to know the frequency o...

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Detalles Bibliográficos
Autores principales: Saad, Emanuel José, Rodríguez Ruiz, Andrés, Douthat y Barrionuevo , Augusto, Milanesio, Martín, Flores Balverdi, Janet, Riscanevo, Nadia Claudine, Peñaranda, Gabriela Estefanía, Novatti, Elisa Beatriz, Saurit, Verónica, Alvarez, Ana Cecilia, Baenas, Diego Federico
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022
Materias:
creatine phosphokinase
muscular diseases
myositis
inflammation
Internal medicine
Clinical medicine
Rheumatology
creatina fosfoquinasa
enfermedades musculares
miositis
Inflamación
Medicina Interna
Clínica Médica
Reumatología
creatina quinase
doenças musculares
miosite
inflamação
clínica médica
Reumatologia
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/36031
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
Descripción
Sumario:Introduction: HyperCKemia  is defined as the elevation of creatine phosphokinase (CK) levels greater than 1.5 times the upper limit (CK>285 U/L), being produced by multiple causes, which vary according different populations. The main objective of the study was to know the frequency of hyperCKemia in two hospitals in Córdoba and its main causes. Methods: Retrospective analytical study in two hospitals in Córdoba, Argentina, where all patients over 18 years of age who presented CK values ​​greater than 285 U/L on at least 2 occasions in a period between 1 and 4 weeks were identified, between the years 2015 and 2017. Results: 254 patients with hyperCKemia were identified, the majority were male (n=181, 71.3%) and their median age was 65 years (interquartile range 25-75%=50-73 years). The main causes of hyperCKemia were ischemic myopathy in 99 (39%) patients and drug-induced myopathies in 45 (17.7%), with statins being the most frequently involved drugs in 31 cases. In only 3.1% of the cases the final diagnosis was not reached. Drug-induced hyperCKemias, when compared to other causes, occurred more frequently in patients with a history of chronic kidney disease (9/45 [20%] vs 18/209 [8.6%], p = 0.025) and in non-smokers (41/45 [91.1%] vs. 157/209 [75.1%], p=0.019). Main conclusion: 254 cases of hyperCKemia were observed, the main causes being of ischemic origin and secondary to drug use, especially statins.

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