Lymphoid cutaneous hyperplasia: a clinical-pathological challenge
Cutaneous pseudolymphoma is the term used to describe a group of lymphoproliferative skin disorders that can clinically and histologically mimic cutaneous lymphoma, whether T- or B-cell lymphoma. B-cell pseudolymphomas are the most common form of cutaneous lymphoid hyperplasia or cutaneous lymphocyt...
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| Autores principales: | , , , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2025
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/50417 |
| Aporte de: |
| Sumario: | Cutaneous pseudolymphoma is the term used to describe a group of lymphoproliferative skin disorders that can clinically and histologically mimic cutaneous lymphoma, whether T- or B-cell lymphoma. B-cell pseudolymphomas are the most common form of cutaneous lymphoid hyperplasia or cutaneous lymphocytoma. These have benign characteristics, rarely malignant progression, and reflect an exaggerated local immune reaction to a triggering stimulus, including arthropod bites, tattoos, and contact allergens. Cutaneous pseudolymphoma is a rare entity that often goes unnoticed and can, in some cases, progress to malignancy or systemic dissemination (miliary lymphoma cutis). Therefore, knowledge of the clinical features and histopathology is essential to reduce the associated risks and complications.
A 20-year-old male patient with no relevant medical history reported erythematous papular lesions on the testicular region and penis that had been present for more than two monthsTreatment with topical corticosteroids and antifungals was prescribed, with no improvement. A skin punch biopsy was taken from the left inguinal region (0.5 × 0.3 cm), fixed in 10% buffered formalin, and processed with standard staining techniques. The pathology report was conclusive for superficial and deep cutaneous lymphoid hyperplasia, related to a reaction to an arthropod bite. The patient progressed favorably.
Cutaneous pseudolymphomas are a clinicopathological challenge for the diagnosis and treatment of these lesions. Among their multiple causes, the forms triggered by arthropod bites are frequently associated with solitary lesions, generally in exposed areas. The main objective in the management of this entity is to exclude malignancy. For this purpose, biopsy and immunohistochemistry, if necessary, are essential tools in patient management and follow-up. |
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