Identification of novel chemical scaffolds Inhibiting trypanothione synthetase from pathogenic trypanosomatids

The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2],...

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Autores principales: Benítez, Diego, Medeiros, Andrea, Fiestas, Lucía, Panozzo Zénere, Esteban Andrés, Maiwald, Franziska, Prousis, Kyriakos C., Roussaki, Marina, Calogeropoulou, Theodora, Detsi, Anastasia, Jaeger, Timo, Šarlauskas, Jonas, Peterlin Mašič, Lucíja, Kunick, Conrad, Labadie, Guillermo Roberto, Flohé, Leopold, Comini, Marcelo A.
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Public Library of Science (PLOS) 2020
Materias:
Neglected Diseases
Trypanothione Synthetase Inhibitors
Pathogenic Trypanosomatids
Leishmania
Trypanosoma
Acceso en línea:http://hdl.handle.net/2133/19536
http://hdl.handle.net/2133/19536
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

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