A Novel Synergistic Combination of Cyclophosphamide and Gene Transfer of Interleukin-12 Eradicates Colorectal Carcinoma in Mice

PURPOSE: Interleukin-12 (IL-12) is an immunostimulatory cytokine with potent antitumor effects in several animal models. However, serious toxicity has been associated with its systemic application in humans. Gene transfer has emerged as a tool to specifically express therapeutic genes into the tumo...

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Detalles Bibliográficos
Autores principales:	Malvicini, Mariana, Rizzo, Miguel, Alaniz, Laura, Piñero, Federico, García, Mariana, Atorrasagasti, Catalina, Aquino, Jorge B., Rozados, Viviana R., Scharovsky, O. Graciela, Matar, Pablo, Mazzolini, Guillermo
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	American Association for Cancer Research 2012
Materias:	Combined immunotherapy Cyclophosphamide gene therapy Interleukin-12 Colorectal carcinoma
Acceso en línea:	http://hdl.handle.net/2133/2009 http://hdl.handle.net/2133/2009
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

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