Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface
Metallo-b-lactamases (MBLs) are zinc-dependent hydrolases that inactivate virtually all b-lactam antibiotics. The expression of MBLs by Gram-negative bacteria severely limits the therapeutic options to treat infections. MBLs bind the essential metal ions in the bacterial periplasm, and their activit...
Guardado en:
| Autores principales: | Bahr, Guillermo, González, Lisandro J., Vila, Alejandro J. |
|---|---|
| Formato: | article artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/23389 http://hdl.handle.net/2133/23389 |
| Aporte de: |
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