Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface

Metallo-b-lactamases (MBLs) are zinc-dependent hydrolases that inactivate virtually all b-lactam antibiotics. The expression of MBLs by Gram-negative bacteria severely limits the therapeutic options to treat infections. MBLs bind the essential metal ions in the bacterial periplasm, and their activit...

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Autores principales: Bahr, Guillermo, González, Lisandro J., Vila, Alejandro J.
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Elsevier 2022
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Acceso en línea:http://hdl.handle.net/2133/23389
http://hdl.handle.net/2133/23389
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