A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19

U-Omp19 is a bacterial protease inhibitor from Brucella abortus that inhibits gastrointestinal and lysosomal proteases, enhancing the half-life and immunogenicity of co-delivered antigens. U-Omp19 is a novel adjuvant that is in preclinical development with various vaccine candidates. However, the mo...

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Detalles Bibliográficos
Autores principales: Darriba, María Laura, Pueblas Castro, Celeste, Coria, Lorena M., Bruno, Laura, Cerutti, María Laura, Otero, Lisandro H., Chemes, Lucía B., Rasia, Rodolfo M., Klinke, Sebastián, Cassataro, Juliana, Pasquevich, Karina A.
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Elsevier 2023
Materias:
Mucosal adjuvant
Protease inhibitor
Structure-activity relationship
Protein structure
Protein crystallization
Acceso en línea:http://hdl.handle.net/2133/25159
http://hdl.handle.net/2133/25159
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

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