The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the <i>Citrobacter rodentium</i> model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice show...
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| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/104084 http://hdl.handle.net/11336/10704 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107933 |
| Aporte de: |
| Sumario: | Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the <i>Citrobacter rodentium</i> model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with <i>C. rodentium</i> and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on <i>C. rodentium</i> infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen. |
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