Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β1 subunit

Thiazide-like diuretics are the most commonly used drugs to treat arterial hypertension, with their efficacy being linked to their chronic vasodilatory effect. Previous studies suggest that activation of the large conductance voltage- and Ca2+-dependent K+ (BK) channel (Slo 1, MaxiK channel) is resp...

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Detalles Bibliográficos
Autores principales:	Martín, Pedro, Moncada, Melisa, Kuntamallappanavar, Guruprasad, Dopico, Alex M., Milesi, María Verónica
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2018
Materias:	Biología Ciencias Médicas Thiazide Hydrochlorothiazide BK channel Slo1 β1-subunit Vascular smooth muscle cells Human umbilical artery Patchclamp electrophysiology
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/107635
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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