Angiotensin-(1-7): an anti-inflammatory and pro-resolutive peptide
In recent decades the renin-angiotensin system has been established itself as a complex regulatory mechanism composed of different pathways involved in the control of physiological functions and, when for long term inappropriately activated, it is involved in the pathophysiology of different disease...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Articulo Revision |
| Lenguaje: | Inglés |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/126797 https://pmr.safisiol.org.ar/archive/id/115 |
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| Sumario: | In recent decades the renin-angiotensin system has been established itself as a complex regulatory mechanism composed of different pathways involved in the control of physiological functions and, when for long term inappropriately activated, it is involved in the pathophysiology of different diseases. Among its biologically active peptides, angiotensin-(1-7) and its receptor Mas, represent an important counter-regulatory mechanism due to their antihypertensive, anti-inflammatory, anti-proliferative and antifibrotic effects. In this review, we present data that besides demonstrating the antiinflammatory effect, indicate that angiotensin-(1-7) has a crucial additional effect on the return to tissue homeostasis, that is to promote resolution of the inflammatory process. These studies point angiotensin-(1-7) or activation of Mas receptor as important therapeutic targets for the treatment of inflammatory diseases. |
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