Hydra as an animal model system in physiology

Hydra has been used as a model in different topics in biology, including physiology. It pertains to the Phylum Cnidaria, an ancestral group of Metazoa that shares a common ancestor with Bilateria. Hydra provides an experimental framework to analyze mechanisms that regulate the homeostasis and, due t...

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Detalles Bibliográficos
Autores principales: Alzugaray, María Eugenia, Gavazzi, María Victoria, Ronderos, Jorge Rafael
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Naturales
Biología
Hydra
Myoregulation
Model system
Physiology
Mioregulación
Sistema modelo
Fisiología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133485
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133485
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Biología
Hydra
Myoregulation
Model system
Physiology
Mioregulación
Sistema modelo
Fisiología
spellingShingle Ciencias Naturales
Biología
Hydra
Myoregulation
Model system
Physiology
Mioregulación
Sistema modelo
Fisiología
Alzugaray, María Eugenia
Gavazzi, María Victoria
Ronderos, Jorge Rafael
Hydra as an animal model system in physiology
topic_facet Ciencias Naturales
Biología
Hydra
Myoregulation
Model system
Physiology
Mioregulación
Sistema modelo
Fisiología
description Hydra has been used as a model in different topics in biology, including physiology. It pertains to the Phylum Cnidaria, an ancestral group of Metazoa that shares a common ancestor with Bilateria. Hydra provides an experimental framework to analyze mechanisms that regulate the homeostasis and, due to the high level of gene conservation, can be easily extrapolated to other animal groups. We use this model to analyze physiological and evolutionary aspects of communication systems activated by food, and by the peptide messengers, Allatotropin (AT) and Allatostatin-C (AST-C). Using immunohistochemistry, quantum dots, bioinformatic, and physiological assays, we show that these systems are present in Hydra regulating feeding behavior. We analyze the regulation of the extrusion of the hypostome (that contains the mouth), showing that, whereas AT mimics the effect of the food, AST-C acts as antagonist. We show that those effects depend on changes in the cytosolic Ca2+ concentration, revealing the specific signaling pathway activated. Our data support the ancestral functions and conservation of these signaling systems that control myoregulatory activities related with feeding.
format Articulo
Articulo
author Alzugaray, María Eugenia
Gavazzi, María Victoria
Ronderos, Jorge Rafael
author_facet Alzugaray, María Eugenia
Gavazzi, María Victoria
Ronderos, Jorge Rafael
author_sort Alzugaray, María Eugenia
title Hydra as an animal model system in physiology
title_short Hydra as an animal model system in physiology
title_full Hydra as an animal model system in physiology
title_fullStr Hydra as an animal model system in physiology
title_full_unstemmed Hydra as an animal model system in physiology
title_sort hydra as an animal model system in physiology
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/133485
work_keys_str_mv AT alzugaraymariaeugenia hydraasananimalmodelsysteminphysiology
AT gavazzimariavictoria hydraasananimalmodelsysteminphysiology
AT ronderosjorgerafael hydraasananimalmodelsysteminphysiology
bdutipo_str Repositorios
_version_ 1764820454778863616

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