Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD

A significant proportion of inflammatory bowel disease (IBD) patients are primary non-responders to biological therapies. Human Neutrophil Elastase (HNE) is highly expressed in IBD mucosa, especially in ulcerative colitis (UC). The aim of this study was to determine whether HNE degrades biologics, r...

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Detalles Bibliográficos
Autores principales:	Kok, Klaartje, Curciarello, Renata, Sobande, T., Jones, S., Docena, Guillermo Horacio, MacDonald, Thomas T.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2018
Materias:	Ciencias Médicas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/147284
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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