Baicalin Normalizes Blood Glucose Level in Streptozotocin -induced Diabetic Rats
This study aimed to determine the effect of baicalin on insulin resistance, glucose absorption, and blood lipids in type 2 diabetic rat model. Diabetic rats were treated with baicalin (40, 80 mg/kg) for 40 days. The results showed that diabetic rats treated with baicalin resulted in a significant...
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| Autores principales: | , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/18090 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_6.pdf |
| Aporte de: |
| Sumario: | This study aimed to determine the effect of baicalin on insulin resistance, glucose absorption,
and blood lipids in type 2 diabetic rat model. Diabetic rats were treated with baicalin (40, 80 mg/kg) for 40
days. The results showed that diabetic rats treated with baicalin resulted in a significant decrease in the
concentration of plasma triglycerides and high-density lipoprotein cholesterol, improved the body weight.
Furthermore, baicalin markedly decreased blood glucose level in the diabetic rats. The levels of plasma insulin and resistin exhibited significantly lower in the diabetic rats treated with baicalin than those of the
model group. These findings suggest that baicalin can improve adipose metabolic disturbance in the experimental type 2 diabetic rats, can effectively ameliorate insulin resistance and plasma glucose transport
by decreasing the levels of plasma resistin. |
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