Determination of tolbutamide and hydroxytolbutamide by LC–MS/MS in rat and its application to assessment of CYP2C9 activity
A sensitive and selective liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for the determination of tolbutamide (TB) and its metabolite hydroxytolbutamide (HTB) in rat plasma was developed using carbamazepine as an internal standard. Chromatographic separation was performed by an Agi...
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| Autores principales: | Qiu, Xiangjun, Fei, Ai-li, Xu, Zhisheng, Du, Xiaoxiang, Xu, Ren-ai, Zhu, Haiyan |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/25744 http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_11.pdf |
| Aporte de: |
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