Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes
The kinetics and mechanism of the thermal decomposition reaction of <i>cis</i>-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in <i>n</i>-hexane and in methanol solutions over the temperatu...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2003
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/35017 http://www.mdpi.com/1420-3049/8/9/655 |
| Aporte de: |
| Sumario: | The kinetics and mechanism of the thermal decomposition reaction of <i>cis</i>-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in <i>n</i>-hexane and in methanol solutions over the temperature and concentration ranges of 393.2-443.2 K and 2.7-54 × 10<SUP>-5</SUP> M, respectively. The values of the activation parameters for both reactions were compared with the corresponding ones for the thermolysis of <i>cis</i>-6-(4-fluorophenyl-5,6-[2-(4- fluorophenyl)-3-hydroxypropylidene]-3,3-tetramethylene-1,2,4-trioxacyclohexane (II), investigated in the same solvents and temperature range. Substituent and solvent effects on the initial homolytic rupture of the O-O peroxydic bonds of those molecules were evaluated. |
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