A simple LC-ESI-MS method for the determination of norvancomycin in rat plasma and application to pharmacokinetic study

A simple and sensitive LC-ESI-MS method for determination of norvancomycin in plasma was developed and validated over the concentration range of 20-2,000 ng/mL. After addition of vancomycin as internal standard (IS), protein precipitation with 5 % trichloroacetic acid was employed for the sample...

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Detalles Bibliográficos
Autores principales: Yang, Xuezhi, Hu, Lufeng, Lin, Guanyang, Xu, Ren-ai, Zhang, Yu, Chen, Linzi, Zhu, Lihe, Zhao, Feng, Wang, Xianqin
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
LC-ESI-MS; norvancomycin; rat plasma; pharmacokinetics
Antibióticos
Farmacología
Farmacocinética
Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8024
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_2_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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