In vitro antibacterial activities of silver (I) 4-substituted benzenesulfonate derivatives
A new series of silver (I) 4-substitutedbenzenesulfonate derivatives (1-8) have been synthesized in order to search for new potential antibacterial agents. The antibacterial activity of 1-8 against various strains of bacteria has been determined. Compounds 2-4 (silver (I) 4-methylbenzenesulfonate...
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| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8044 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_17.pdf |
| Aporte de: |
| Sumario: | A new series of silver (I) 4-substitutedbenzenesulfonate derivatives (1-8) have been synthesized in
order to search for new potential antibacterial agents. The antibacterial activity of 1-8 against various strains of
bacteria has been determined. Compounds 2-4 (silver (I) 4-methylbenzenesulfonate (2), silver (I) 4-methoxybenzenesulfonate
(3), and silver (I) 4-aminobenzenesulfonate (4)) showed broad spectrum of antibacterial activities
against both Gram-positive (methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, Bacillus subtilis,
Enterococcus faecalis and vancomycin-resistant Enterococcus faecalis) and only one Gram-negative bacterium
(Shigella sonnei). The Structure-Activity Relationship (SAR) has also been reported. |
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