New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

Chitotriosidase (CHIT1) is a human chitinase belonging to the highly conserved glycosyl hydrolase family 18 (GH18). GH18 enzymes hydrolyze chitin, an N-acetylglucosamine polymer synthesized by lower organisms for structural purposes. Recently, CHIT1 has attracted attention owing to its upregulation...

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Detalles Bibliográficos
Autores principales: Fadel, Firas, Zhao, Yuguang, Cachau, Raul, Cousido Siah, Alexandra, Ruiz, Francesc X., Harlos, Karl, Howard, Eduardo Ignacio, Mitschler, Andre, Podjarny, Alberto Daniel
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2015
Materias:
Biología
Crystal structure
Chitotriosidase
Catalytic mechanism
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/99593
https://ri.conicet.gov.ar/11336/47887
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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