Reducción de la variabilidad de la presión arterial con B-bloqueantes o amlodipina y su impacto sobre el daño de órgano blanco
Blood pressure variability is a novel risk factor for the development of target organ damage, so its reduction should be considered a possible therapeutic goal of antihypertensive treatment. The aim of this study was to evaluate the effects of chronic oral administration of atenolol, nebivolol, carv...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2018
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2822 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2822.dir/2822.PDF |
| Aporte de: |
| Sumario: | Blood pressure variability is a novel risk factor for the development of target organ damage, so its reduction should be considered a possible therapeutic goal of antihypertensive treatment. The aim of this study was to evaluate the effects of chronic oral administration of atenolol, nebivolol, carvedilol or amlodipine on short-term blood pressure variability and target organ damage. Spontaneously hypertensive rats and L-NAME hypertensive rats were treated during 8 weeks with a single daily dose of atenolol, nebivolol, carvedilol, amlodipine or vehicle. Blood pressure and its short-term variability were determined. The left ventricle and thoracic aorta were removed for histological studies and the evaluation of the expression of profibrotic and proinflammatory cytokines. Although treatment with ?-blockers and amlodipine reduced systolic blood pressure, only carvedilol, nebivolol and amlodipine decreased its short-term variability. In addition, nebivolol and carvedilol reduced ventricular and aortic fibrosis, media wall thickness, area of cardiomyocytes and induced a greater reduction of the overexpression of profibrotic and proinflammatory mediators compared to animals treated with vehicle or atenolol, and in a similar way to amlodipine. These findings suggest that the greater reduction in blood pressure variability would contribute to the enhanced protection of organ damage with nebivolol and carvedilol compared to atenolol. |
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