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The objective of the research was the analysis of the antiulcerogenic and antispasmodic effects of Marrubium vulgare (MV), Acmella decumbens (AD), Lippia turbinata (LT), Tribulus terrestres and Ruta chalepensis (RC) hidroalcoholic extracts. Antiulcerogenic activity was studied in mices for their abi...

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Autores principales:	Toso, R.E., Toribio, M.S., Mengelle, P., Boeris, M.A.
Formato:	Artículo publishedVersion
Lenguaje:	Español
Publicado:	Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. 2007
Materias:	gastroprotector antiespasmódico extractos vegetales gastroprotective antispasmodic plant extracts
Acceso en línea:	http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4893 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4893.dir/4893.PDF
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-HWA_4893
record_format	dspace
spelling	I28-R145-HWA_48932024-11-05 05 toso.indd The objective of the research was the analysis of the antiulcerogenic and antispasmodic effects of Marrubium vulgare (MV), Acmella decumbens (AD), Lippia turbinata (LT), Tribulus terrestres and Ruta chalepensis (RC) hidroalcoholic extracts. Antiulcerogenic activity was studied in mices for their ability to inhibit the gastric lesions induced on cold restraint stress. Gastrointestinal motility was evaluated with activated charcoal as intestinal transit indicator. Atropine and ranitidine were used like gastroprotectives. Atropine was used for decrease gastrointestinal motility. We proved that all plant extracts and atropine have gastroprotective activity (p< 0.01). Ranitidine did not prevent ulcers in mice. The extracts MV and AD also significantly reduced the intestinal transit in charcoal meal test when compared with atropine. LT, TT and RC extracts moderate but significantly inhibited gastrointestinal transit compared with control group (p< 0.01). These results further suggest that all extracts were found to possess antiulcerogenic and inhibitory activity on gastrointestinal motility, which might also be due to antispasmolitic activity. \n Fil: Toso, R.E. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias. Cátedra de Farmacología. La Pampa, Argentina Fil: Toribio, M.S. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias. Cátedra de Farmacología. La Pampa, Argentina Fil: Mengelle, P. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias. Cátedra de Farmacología. La Pampa, Argentina Fil: Boeris, M.A. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias. Cátedra de Fisiología. La Pampa, Argentina Toso, R.E. Toribio, M.S. Mengelle, P. Boeris, M.A. 2007 Se evaluó la actividad gastroprotectora y antiespasmódica de extractos hidroalcohólicos de Marrubium vulgare (MV), Acmella decumbens (AD), Lippia turbinata (LT), Tribulus terrestres (TT) y Ruta chalepensis (RC). Para determinar el efecto gastroprotector se indujeron úlceras por estrés y la motilidad gastrointestinal se evaluó midiendo el progreso del contenido intestinal en ratones. Atropina y ranitidina fueron utilizadas como drogas de referencia con actividad gastroprotectora y atropina fue utilizada, también, por su efecto inhibitorio sobre la motilidad gastrointestinal. Todos los extractos y la atropina mostraron actividad gastroprotectora (p<0,01). La ranitidina no previno las úlceras en ningún animal. Los ratones tratados con los extractos MV y AD mostraron mayor efecto inhibitorio de la motilidad que el logrado con atropina. Los extractos LT, TT y RC inhibieron el progreso del contenido gastrointestinal en forma más moderada, pero significativa respecto a los ratones pertenecientes al grupo control (p<0,01). Se concluye que todos los extractos ensayados poseen actividad gastroprotectora e inhibitoria de la motilidad gastrointestinal. El efecto gastroprotector logrado con la atropina, pero no con la administración de ranitidina sugiere un importante papel de la acción espasmolítica en el mecanismo de acción de los extractos. application/pdf 1514-6634 (impreso) 1668-3498 (en línea) gastroprotector antiespasmódico extractos vegetales gastroprotective antispasmodic plant extracts spa Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ InVet, vol. 09, nº2 Plantas de la provincia de La Pampa, Argentina, con actividad gastroprotectora y antiespasmódica Antiulcerogenic and antispasmodic effects of plants from La Pampa, Argentina info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4893 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4893.dir/4893.PDF
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
language	Español
orig_language_str_mv	spa
topic	gastroprotector antiespasmódico extractos vegetales gastroprotective antispasmodic plant extracts
spellingShingle	gastroprotector antiespasmódico extractos vegetales gastroprotective antispasmodic plant extracts Toso, R.E. Toribio, M.S. Mengelle, P. Boeris, M.A. 05 toso.indd
topic_facet	gastroprotector antiespasmódico extractos vegetales gastroprotective antispasmodic plant extracts
description	The objective of the research was the analysis of the antiulcerogenic and antispasmodic effects of Marrubium vulgare (MV), Acmella decumbens (AD), Lippia turbinata (LT), Tribulus terrestres and Ruta chalepensis (RC) hidroalcoholic extracts. Antiulcerogenic activity was studied in mices for their ability to inhibit the gastric lesions induced on cold restraint stress. Gastrointestinal motility was evaluated with activated charcoal as intestinal transit indicator. Atropine and ranitidine were used like gastroprotectives. Atropine was used for decrease gastrointestinal motility. We proved that all plant extracts and atropine have gastroprotective activity (p< 0.01). Ranitidine did not prevent ulcers in mice. The extracts MV and AD also significantly reduced the intestinal transit in charcoal meal test when compared with atropine. LT, TT and RC extracts moderate but significantly inhibited gastrointestinal transit compared with control group (p< 0.01). These results further suggest that all extracts were found to possess antiulcerogenic and inhibitory activity on gastrointestinal motility, which might also be due to antispasmolitic activity. \n
format	Artículo Artículo publishedVersion
author	Toso, R.E. Toribio, M.S. Mengelle, P. Boeris, M.A.
author_facet	Toso, R.E. Toribio, M.S. Mengelle, P. Boeris, M.A.
author_sort	Toso, R.E.
title	05 toso.indd
title_short	05 toso.indd
title_full	05 toso.indd
title_fullStr	05 toso.indd
title_full_unstemmed	05 toso.indd
title_sort	05 toso.indd
publisher	Universidad de Buenos Aires. Facultad de Ciencias Veterinarias.
publishDate	2007
url	http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4893 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4893.dir/4893.PDF
work_keys_str_mv	AT tosore 05tosoindd AT toribioms 05tosoindd AT mengellep 05tosoindd AT boerisma 05tosoindd AT tosore plantasdelaprovinciadelapampaargentinaconactividadgastroprotectorayantiespasmodica AT toribioms plantasdelaprovinciadelapampaargentinaconactividadgastroprotectorayantiespasmodica AT mengellep plantasdelaprovinciadelapampaargentinaconactividadgastroprotectorayantiespasmodica AT boerisma plantasdelaprovinciadelapampaargentinaconactividadgastroprotectorayantiespasmodica AT tosore antiulcerogenicandantispasmodiceffectsofplantsfromlapampaargentina AT toribioms antiulcerogenicandantispasmodiceffectsofplantsfromlapampaargentina AT mengellep antiulcerogenicandantispasmodiceffectsofplantsfromlapampaargentina AT boerisma antiulcerogenicandantispasmodiceffectsofplantsfromlapampaargentina
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