Rol de los linfocitos B humanos en la infección por hantavirus
Hantaviruses are RNA viruses which cause two diseases in humans: Hantavirus\nPulmonary Syndrome (HPS) in the Americas and Hemorrhagic Fever with Renal Syndrome\n(HFRS) mainly in Europe and Asia. There are no specific treatments or preventive approved\nvaccines available and the pathogenesis of these...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2019
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_5790 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_5790.dir/5790.PDF |
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| Sumario: | Hantaviruses are RNA viruses which cause two diseases in humans: Hantavirus\nPulmonary Syndrome (HPS) in the Americas and Hemorrhagic Fever with Renal Syndrome\n(HFRS) mainly in Europe and Asia. There are no specific treatments or preventive approved\nvaccines available and the pathogenesis of these diseases is not completely known to date.\nThus, the main aim of this thesis work was to study the role of human B cells in response to\nhantavirus infection.\nWe found a strong plasmablast response in peripheral blood from HPS patients, with\nbroad reactivity, both specific towards hantavirus antigens and towards non-viral antigens,\nsuggesting a bystander response with polyclonal activation of B cells. Moreover, we could\nprove that B cells can be infected by hantaviruses causative of both diseases, with differential\ncapacity of productive infection according to the species. Finally, we found that hantavirusinfected\npulmonary microvascular endothelial cells, the main targets for hantavirus infection,\nare capable of activating and enhancing the survival of B cells through soluble secreted factors.\nIn summary, we have characterized human B cells in HPS patients for the first time,\nidentified B cells as a new target for hantavirus infection and found that the infected\nendothelium can indirectly modulate them. |
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