Bone morphogenetic protein-4 inhibits corticotroph tumor cells: Involvement in the retinoic acid inhibitory action

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The molecular mechanisms governing the pathogenesis of ACTH-secreting pituitary adenomas are still obscure. Furthermore, the pharmacological treatment of these tumors is limited. In this study, we report that bone morphogenetic protein-4 (BMP-4) is expressed in the corticotrophs of human normal aden...

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Autores principales: Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Labeur, M., Refojo, D., Gerez, J., Chervin, A., Berner, S., Losa, M., Buchfelder, M., Renner, U., Stalla, G.K., Arzt, E.
Formato: Artículo publishedVersion
Publicado: 2006
Materias:
bone morphogenetic protein 4
corticotropin
noggin
retinoic acid
Smad4 protein
adenohypophysis
animal cell
animal experiment
animal model
animal tissue
article
cancer inhibition
carcinogenicity
cell line
cell proliferation
comparative study
controlled study
corticotropin release
Cushing disease
disease course
enzyme inhibition
genetic transfection
human
human tissue
mouse
nonhuman
priority journal
protein expression
signal transduction
transcription initiation
Adenoma
Animals
Bone Morphogenetic Proteins
Cell Division
Cell Line, Tumor
Cushing Syndrome
Humans
Immunohistochemistry
Mice
Pituitary Gland
Pituitary Neoplasms
Reference Values
Tretinoin
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v147_n1_p247_Giacomini
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00137227_v147_n1_p247_Giacomini_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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