A novel mechanism of resistance to α-difluoromethylornithine induced by cycloheximide. Growth with abnormally low levels of putrescine and spermidine

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Treatment of the chemically transformed fibroblasts BP-A31 and other cell lines with low concentrations of cycloheximide (CHM) for 72 h followed by the removal of the protein synthesis inhibitor leads to the proliferation of α-difluoromethylornithine (DFMO)-resistant phenotypes. These drug-resistant...

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Detalles Bibliográficos
Autores principales: Medrano, E.E., Burrone, O.R., Ferrer, M.M., Cafferata, E.G.A., Algranati, I.D.
Formato: Artículo publishedVersion
Publicado: 1986
Materias:
Cycloheximide
Ornithine decarboxylase
Polyamine
α-Difluoromethylornithine resistance
cycloheximide
eflornithine
putrescine
spermidine
cell line
drug inhibition
drug resistance
fibroblast
in vitro study
nonhuman
priority journal
Animals
Cell Line
Drug Resistance
Eflornithine
Fibroblasts
Humans
Mice
Ornithine Decarboxylase
Putrescine
Spermidine
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00145793_v206_n1_p106_Medrano
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00145793_v206_n1_p106_Medrano_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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