Brucella lumazine synthase elicits a mixed Th1-Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation used

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The immunogenicity and protective efficacy of recombinant lumazine synthase from Brucella spp. (rBLS) administered with different adjuvants was evaluated in mice. Mice were immunized with rBLS in the absence or the presence of aluminum hydroxide gel (BLS-A1), monophosphoryl lipid A (BLS-MPA), or inc...

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Detalles Bibliográficos
Autores principales: Velikovsky, C.A., Goldbaum, F.A., Cassataro, J., Estein, S., Bowden, R.A., Bruno, L., Fossati, C.A., Giambartolomei, G.H.
Formato: Artículo publishedVersion
Publicado: 2003
Materias:
aluminum hydroxide
Brucella vaccine
Freund adjuvant
gamma interferon
immunoglobulin G
immunoglobulin G antibody
immunoglobulin G1
immunoglobulin G2
interleukin 10
interleukin 2
interleukin 4
lumazine
lumazine synthase
phosphoryl lipid A
recombinant enzyme
unclassified drug
animal experiment
animal model
article
Brucella abortus
brucellosis
controlled study
cytokine production
drug effect
drug formulation
female
immune response
immunization
immunogenicity
mouse
nonhuman
priority journal
spleen cell
Th1 cell
Th2 cell
Adjuvants, Immunologic
Animals
Antibodies, Bacterial
Brucella
Brucella Vaccine
Brucellosis
Female
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Multienzyme Complexes
Th1 Cells
Th2 Cells
Vaccines, Synthetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00199567_v71_n10_p5750_Velikovsky
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00199567_v71_n10_p5750_Velikovsky_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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