Inhibition of aac(6′)-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria

Mostrar todas las versiones(3)

Inhibition of bacterial gene expression by RNase P-directed cleavage is a promising strategy for the development of antibiotics and pharmacological agents that prevent expression of antibiotic resistance. The rise in multiresistant bacteria harboring AAC(6′)-Ib has seriously limited the effectivenes...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Soler Bistué, A.J.C., Martín, F.A., Vozza, N., Ha, H., Joaquín, J.C., Zorreguieta, A., Tolmasky, M.E.
Formato: Artículo publishedVersion
Publicado: 2009
Materias:
Aminoglycoside
Antibiotic resistance
Antisense
Nucleic acids analogs
RNase P
aac(6') Ib enzyme
amikacin
antisense oligonucleotide
bacterial DNA
bacterial enzyme
locked nucleic acid
messenger RNA
nuclease
oligoribonucleotide
ribonuclease
unclassified drug
antibiotic resistance
article
bacterial gene
controlled study
enzymatic degradation
Escherichia coli
gene expression
genetic analysis
growth inhibition
in vitro study
nonhuman
permeability
priority journal
Acetyltransferases
Amikacin
Base Sequence
DNA
Drug Resistance, Bacterial
Endocytosis
Oligonucleotides
Ribonuclease P
RNA, Messenger
Bacteria (microorganisms)
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00278424_v106_n32_p13230_SolerBistue
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00278424_v106_n32_p13230_SolerBistue_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares