Modification of an essential amino group in the mineralocorticoid receptor evidences a differential conformational change of the receptor protein upon binding of antagonists, natural agonists and the synthetic agonist 11,19-oxidoprogesterone
The alkylation of amino groups of the mineralocorticoid receptor (MR) with pyridoxal 5′-phosphate or 2,4,6-trinitrobenzenesulphonate (TNBS) under controlled conditions modifies only one lysyl residue, which accounts for a 70% inhibition of steroid binding capacity. The Kd of aldosterone for MR is no...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo publishedVersion |
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2002
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01674889_v1589_n1_p31_PiwienPilipuk https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_01674889_v1589_n1_p31_PiwienPilipuk_oai |
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