Aluminum exposure affects transferrin-dependent and -independent iron uptake by K562 cells

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Aluminum (Al) and iron (Fe) share several physicochemical characteristics and they both bind to transferrin (Tf), entering the cell via Tf receptors (TfR). Previously, we found similar values of affinity constant for the binding of TfR to Tf carrying either Al or Fe. The competitive interaction betw...

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Detalles Bibliográficos
Autores principales: Pérez, G., Pregi, N., Vittori, D., Di Risio, C., Garbossa, G., Nesse, A.
Formato: Artículo publishedVersion
Publicado: 2005
Materias:
Aluminum
Iron metabolism
K562 cell line
Non-transferrin bound iron transport
Transferrin receptor
Transferrin-mediated iron uptake
aluminum
antigen
iron
messenger RNA
receptor subtype
transferrin
transferrin receptor
article
chronic myeloid leukemia
controlled study
flow cytometry
human
human cell
iron depletion
iron transport
leukemia cell
priority journal
protein expression
receptor binding
regulatory mechanism
reverse transcription polymerase chain reaction
upregulation
Biological Transport
Butyrates
Cell Differentiation
Gene Expression Regulation, Neoplastic
Humans
Iron
K562 Cells
Receptors, Transferrin
RNA, Messenger
Transferrin
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01674889_v1745_n1_p124_Perez
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_01674889_v1745_n1_p124_Perez_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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