An open‐label, non‐randomized, drug‐repurposing study to explore the clinical effects of Angiotensin II Type 1 (AT1) receptor antagonists on anxiety and depression in Parkinson's Disease
Background: The cerebral Renin-Angiotensin System might have a role in anxiety and depression development. Objective: We explored the effects of Angiotensin II Type 1 receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACE-Is) on anxiety and depression in Parkinson’s Disease (PD)....
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| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
International Parkinson and Movement Disorder Society
2025
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| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/20021 |
| Aporte de: |
| Sumario: | Background: The cerebral Renin-Angiotensin System might have a role in anxiety and depression development. Objective: We explored the effects of Angiotensin II Type 1 receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACE-Is) on anxiety and depression in Parkinson’s Disease (PD). Methods: Four hundred and twenty-three newly diagnosed drug-naïve PD patients were evaluated using the State–Trait Anxiety Inventory (STAI) and Geriatric Depression Scale (GDS-15) tests and were monitored at baseline and for up to 3 years. Results: Twelve patients were treated with ARBs and 42 with ACE-Is. ARB-treated patients had lower anxiety STAI scores than those on ACE-Is or drug-free at baseline (17.2 1.3 vs. 21.3 1.3, or 23.8 0.5, respectively, P = 0.021) and during the follow-up (P < 0.01). Depression scores were unaffected by any of the drugs throughout the study. Conclusion: This small sample of ARB-treated PD patients displayed lower levels of anxiety. Randomized clinical trials are warranted. |
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