TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

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Objective Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this study, we use Trpc1/4/5/6−/− compound knockout mice to analyze the contribution of...

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Autores principales: Sachdeva, Robin, Schlotterer, Andrea, Schumacher, Dagmar, Matka, Christin, Mathar, Ilka, Dietrich, Nadine, Medert, Rebekka, Kriebs, Ulrich, Lin, Jihong, Nawroth, Peter, Birnbaumer, Lutz, Fleming, Thomas, Hammes, Hans-Peter, Freichel, Marc
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2019
Materias:
RETINOPATIA DIABETICA
ENFERMEDADES METABOLICAS
HIPERGLUCEMIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8705
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina

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