Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis

The knowledge of the underlying molecular kinetics is a key point for the development of a dialysis treatment as well as for patient monitoring. In this work, we propose a kinetic inference method that is general enough to be used on different molecular types measured in the spent dialysate. It esti...

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Detalles Bibliográficos
Autores principales: Fernández, Elmer Andrés, Perazzo, Carlos Alberto, Valtuille, Rodolfo, Willshaw, Peter, Balzarini, Mónica
Formato: Artículo
Lenguaje:Español
Publicado: 2007
Materias:
TA Ingeniería de asistencia técnica (General). Ingeniería Civil (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4020/1/A_Fern%C3%A1ndez_Perazzo_Valtuille_Willshauw_Balzarini.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4020
record_format dspace
spelling I38-R144-40202025-04-10T17:53:41Z http://pa.bibdigital.ucc.edu.ar/4020/ Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis Fernández, Elmer Andrés Perazzo, Carlos Alberto Valtuille, Rodolfo Willshaw, Peter Balzarini, Mónica TA Ingeniería de asistencia técnica (General). Ingeniería Civil (General) The knowledge of the underlying molecular kinetics is a key point for the development of a dialysis treatment as well as for patient monitoring. In this work, we propose a kinetic inference method that is general enough to be used on different molecular types measured in the spent dialysate. It estimates the number and significance of the compartments involved in the overall process of dialysis by means of a spectral deconvolution technique, characterizing therefore the kinetic behavior of the patient. The method was applied to 52 patients to reveal the underlying kinetics from dialysate time-concentration profiles of urea, which has a well-known molecular kinetic. Three types of behaviors were found: one-compartmental (exponential decay Tau = 180 ± 61.64 minutes), bicompartmental (Tau1 = 24.96 ± 19.33 minutes, Tau2 = 222.32 ± 76.59 minutes), and tricompartmental (Tau1 = 23.03 ± 14.21 minutes; Tau2 = 85.75 ± 27.48 minutes; and Tau3 = 337 ± 85.52 minutes). In patients with bicompartmental kinetics, the Tau2 was related to the level of dialysis dose. The study concluded that spectral deconvolution technique can be considered a powerful tool for molecular kinetics inference that could be integrated in on-line molecular analysis devices. Furthermore, the method could be used in the analysis of poorly understood molecules as well as in new hemodialysis target biomarkers. 2007-11-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4020/1/A_Fern%C3%A1ndez_Perazzo_Valtuille_Willshauw_Balzarini.pdf Fernández, Elmer Andrés ORCID: https://orcid.org/0000-0002-4711-8634 <https://orcid.org/0000-0002-4711-8634>, Perazzo, Carlos Alberto ORCID: https://orcid.org/0000-0002-4392-3484 <https://orcid.org/0000-0002-4392-3484>, Valtuille, Rodolfo ORCID: https://orcid.org/0000-0003-2434-9226 <https://orcid.org/0000-0003-2434-9226>, Willshaw, Peter and Balzarini, Mónica ORCID: https://orcid.org/0000-0002-4858-4637 <https://orcid.org/0000-0002-4858-4637> (2007) Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis. ASAIO Journal, 53 (5). pp. 582-586. ISSN 1058-2916 info:eu-repo/semantics/altIdentifier/doi/10.1097/MAT.0b013e318145bb31
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic TA Ingeniería de asistencia técnica (General). Ingeniería Civil (General)
spellingShingle TA Ingeniería de asistencia técnica (General). Ingeniería Civil (General)
Fernández, Elmer Andrés
Perazzo, Carlos Alberto
Valtuille, Rodolfo
Willshaw, Peter
Balzarini, Mónica
Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis
topic_facet TA Ingeniería de asistencia técnica (General). Ingeniería Civil (General)
description The knowledge of the underlying molecular kinetics is a key point for the development of a dialysis treatment as well as for patient monitoring. In this work, we propose a kinetic inference method that is general enough to be used on different molecular types measured in the spent dialysate. It estimates the number and significance of the compartments involved in the overall process of dialysis by means of a spectral deconvolution technique, characterizing therefore the kinetic behavior of the patient. The method was applied to 52 patients to reveal the underlying kinetics from dialysate time-concentration profiles of urea, which has a well-known molecular kinetic. Three types of behaviors were found: one-compartmental (exponential decay Tau = 180 ± 61.64 minutes), bicompartmental (Tau1 = 24.96 ± 19.33 minutes, Tau2 = 222.32 ± 76.59 minutes), and tricompartmental (Tau1 = 23.03 ± 14.21 minutes; Tau2 = 85.75 ± 27.48 minutes; and Tau3 = 337 ± 85.52 minutes). In patients with bicompartmental kinetics, the Tau2 was related to the level of dialysis dose. The study concluded that spectral deconvolution technique can be considered a powerful tool for molecular kinetics inference that could be integrated in on-line molecular analysis devices. Furthermore, the method could be used in the analysis of poorly understood molecules as well as in new hemodialysis target biomarkers.
format Artículo
author Fernández, Elmer Andrés
Perazzo, Carlos Alberto
Valtuille, Rodolfo
Willshaw, Peter
Balzarini, Mónica
author_facet Fernández, Elmer Andrés
Perazzo, Carlos Alberto
Valtuille, Rodolfo
Willshaw, Peter
Balzarini, Mónica
author_sort Fernández, Elmer Andrés
title Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis
title_short Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis
title_full Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis
title_fullStr Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis
title_full_unstemmed Molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis
title_sort molecular kinetics modeling in hemodialysis: on-line molecular monitoring and spectral analysis
publishDate 2007
url http://pa.bibdigital.ucc.edu.ar/4020/1/A_Fern%C3%A1ndez_Perazzo_Valtuille_Willshauw_Balzarini.pdf
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AT valtuillerodolfo molecularkineticsmodelinginhemodialysisonlinemolecularmonitoringandspectralanalysis
AT willshawpeter molecularkineticsmodelinginhemodialysisonlinemolecularmonitoringandspectralanalysis
AT balzarinimonica molecularkineticsmodelinginhemodialysisonlinemolecularmonitoringandspectralanalysis
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