Antimicrobial resistance and genotypic characterization of Escherichia coli in piglets with post-weaning diarrhea from Córdoba, Argentina

Post-weaning diarrhea (PWD) is a major health and economic issue problem in swine production, where enterotoxigenic Escherichia coli (ETEC) is one of the main causative agents. It leads to diarrhea and growth retardation, which resulting in increased antimicrobial use and, consequently, a higher ris...

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Autores principales: Zarazaga, María del Pilar, Vico, Juan Pablo, Lorenzutti, Augusto Matías, Himelfarb, Martín, Zogbi, Ana Paola, Litterio, Nicolás Javier
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Nordeste 2026
Materias:
colibacillosis
ETEC
antimicrobial resistance
post-weaning diarrhea
epidemiological surveillance
One Health
Colibacilosis
resistencia antimicrobiana
diarrea posdestete
vigilancia epidemiológica
Una Salud
Acceso en línea:https://revistas.unne.edu.ar/index.php/vet/article/view/9046
Aporte de:
Revistas UNNE - Universidad Nacional del Noroeste (UNNE) de Universidad Nacional del Nordeste
id I48-R154-article-9046
record_format ojs
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-154
container_title_str Revistas UNNE - Universidad Nacional del Noroeste (UNNE)
language Español
format Artículo revista
topic colibacillosis
ETEC
antimicrobial resistance
post-weaning diarrhea
epidemiological surveillance
One Health
Colibacilosis
ETEC
resistencia antimicrobiana
diarrea posdestete
vigilancia epidemiológica
Una Salud
spellingShingle colibacillosis
ETEC
antimicrobial resistance
post-weaning diarrhea
epidemiological surveillance
One Health
Colibacilosis
ETEC
resistencia antimicrobiana
diarrea posdestete
vigilancia epidemiológica
Una Salud
Zarazaga, María del Pilar
Vico, Juan Pablo
Lorenzutti, Augusto Matías
Himelfarb, Martín
Zogbi, Ana Paola
Litterio, Nicolás Javier
Antimicrobial resistance and genotypic characterization of Escherichia coli in piglets with post-weaning diarrhea from Córdoba, Argentina
topic_facet colibacillosis
ETEC
antimicrobial resistance
post-weaning diarrhea
epidemiological surveillance
One Health
Colibacilosis
ETEC
resistencia antimicrobiana
diarrea posdestete
vigilancia epidemiológica
Una Salud
author Zarazaga, María del Pilar
Vico, Juan Pablo
Lorenzutti, Augusto Matías
Himelfarb, Martín
Zogbi, Ana Paola
Litterio, Nicolás Javier
author_facet Zarazaga, María del Pilar
Vico, Juan Pablo
Lorenzutti, Augusto Matías
Himelfarb, Martín
Zogbi, Ana Paola
Litterio, Nicolás Javier
author_sort Zarazaga, María del Pilar
title Antimicrobial resistance and genotypic characterization of Escherichia coli in piglets with post-weaning diarrhea from Córdoba, Argentina
title_short Antimicrobial resistance and genotypic characterization of Escherichia coli in piglets with post-weaning diarrhea from Córdoba, Argentina
title_full Antimicrobial resistance and genotypic characterization of Escherichia coli in piglets with post-weaning diarrhea from Córdoba, Argentina
title_fullStr Antimicrobial resistance and genotypic characterization of Escherichia coli in piglets with post-weaning diarrhea from Córdoba, Argentina
title_full_unstemmed Antimicrobial resistance and genotypic characterization of Escherichia coli in piglets with post-weaning diarrhea from Córdoba, Argentina
title_sort antimicrobial resistance and genotypic characterization of escherichia coli in piglets with post-weaning diarrhea from córdoba, argentina
description Post-weaning diarrhea (PWD) is a major health and economic issue problem in swine production, where enterotoxigenic Escherichia coli (ETEC) is one of the main causative agents. It leads to diarrhea and growth retardation, which resulting in increased antimicrobial use and, consequently, a higher risk of bacterial resistance. This study aimed to isolate E. coli strains from fecal samples of piglets with PWD on farms in Córdoba province, Argentina, to describe their antimicrobial resistance profiles and perform genotypic characterization. A total of 69 rectal swabs were collected from six farms; E. coli was isolated in 97% of the samples. A concerning resistance profile was observed, with high levels against β-lactams (98.5%), phenicols (88%), tetracyclines (86.6%), and aminoglycosides (34.3%). Moreover, 62 strains (92.5%) were classified as multidrug-resistant. Among the 67 isolates obtained, 70% corresponded to ETEC strains, showing a high prevalence of the toxin-associated genes estII (74.5%) and estI (63.8%). Adhesion genes were also detected, including fedA (21.3%), faeG (14.9%), aidA (25.5%), and astA (14.9%). These findings highlight the strong selective pressure exerted on bacterial populations in production systems, favoring the persistence and dissemination of multidrug-resistant strains. They also emphasize the need to implement stricter control measures to reduce their spread in swine production, with direct implications for public health under the One Health approach.
publisher Universidad Nacional del Nordeste
publishDate 2026
url https://revistas.unne.edu.ar/index.php/vet/article/view/9046
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first_indexed 2026-01-17T05:00:42Z
last_indexed 2026-01-17T05:00:42Z
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spelling I48-R154-article-90462026-01-02T16:21:29Z Antimicrobial resistance and genotypic characterization of Escherichia coli in piglets with post-weaning diarrhea from Córdoba, Argentina Resistencia antimicrobiana y genotipificación de Escherichia coli en lechones con diarrea posdestete de Córdoba, Argentina Zarazaga, María del Pilar Vico, Juan Pablo Lorenzutti, Augusto Matías Himelfarb, Martín Zogbi, Ana Paola Litterio, Nicolás Javier colibacillosis ETEC antimicrobial resistance post-weaning diarrhea epidemiological surveillance One Health Colibacilosis ETEC resistencia antimicrobiana diarrea posdestete vigilancia epidemiológica Una Salud Post-weaning diarrhea (PWD) is a major health and economic issue problem in swine production, where enterotoxigenic Escherichia coli (ETEC) is one of the main causative agents. It leads to diarrhea and growth retardation, which resulting in increased antimicrobial use and, consequently, a higher risk of bacterial resistance. This study aimed to isolate E. coli strains from fecal samples of piglets with PWD on farms in Córdoba province, Argentina, to describe their antimicrobial resistance profiles and perform genotypic characterization. A total of 69 rectal swabs were collected from six farms; E. coli was isolated in 97% of the samples. A concerning resistance profile was observed, with high levels against β-lactams (98.5%), phenicols (88%), tetracyclines (86.6%), and aminoglycosides (34.3%). Moreover, 62 strains (92.5%) were classified as multidrug-resistant. Among the 67 isolates obtained, 70% corresponded to ETEC strains, showing a high prevalence of the toxin-associated genes estII (74.5%) and estI (63.8%). Adhesion genes were also detected, including fedA (21.3%), faeG (14.9%), aidA (25.5%), and astA (14.9%). These findings highlight the strong selective pressure exerted on bacterial populations in production systems, favoring the persistence and dissemination of multidrug-resistant strains. They also emphasize the need to implement stricter control measures to reduce their spread in swine production, with direct implications for public health under the One Health approach. La diarrea posdestete (DPD) es un importante problema sanitario y económico en la producción porcina, donde Escherichia coli enterotoxigénica (ETEC) constituye uno de los principales agentes causales, provocando diarrea y retraso en el crecimiento, lo que conlleva un mayor uso de antimicrobianos y, en consecuencia, un incremento del riesgo de resistencia bacteriana. El objetivo de este estudio fue aislar cepas de E. coli a partir de muestras fecales de lechones con DPD en granjas de la provincia de Córdoba, Argentina, describir su perfil de resistencia a antimicrobianos de importancia crítica en salud pública y/o animal, y realizar su caracterización genotípica. Se recolectaron 69 muestras de hisopado rectal en seis establecimientos, con una tasa de aislamiento de E. coli del 97%. Se observó un perfil de resistencia preocupante, con altos niveles frente a betalactámicos (98,5%), fenicoles (88%), tetraciclinas (86,6%) y aminoglucósidos (34,3%). Además, 62 cepas (92,5%) fueron clasificadas como multirresistentes. De los 67 aislamientos obtenidos, el 70% correspondió a cepas ETEC, con alta prevalencia de los genes estII (74,5%) y estI (63,8%), asociados a la producción de toxinas. También se detectaron genes de adhesión como fedA (21,3%), faeG (14,9%), aidA (25,5%) y astA (14,9%). Estos resultados evidencian la fuerte presión de selección ejercida sobre las poblaciones bacterianas en los sistemas productivos, favoreciendo la persistencia y diseminación de cepas multirresistentes, y subrayan la necesidad de implementar medidas de control más estrictas para reducir su propagación en la producción porcina, con implicancias directas para la salud pública y bajo el enfoque de Una Salud. Universidad Nacional del Nordeste 2026-01-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/9046 10.30972/vet.3719046 Revista Veterinaria; Vol. 37 (2026); 1-9 Revista Veterinaria; Vol. 37 (2026); 1-9 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/9046/8689 Derechos de autor 2026 María del Pilar Zarazaga, Juan Pablo Vico, Augusto Matías Lorenzutti, Martín Himelfarb, Ana Paola Zogbi, Nicolás Javier Litterio https://creativecommons.org/licenses/by-nc/4.0

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