Pregnancy toxemia in goats and sheep in Argentina: epidemiology, pathogenesis, and regional insights

Pregnancy toxemia, also known as pregnancy-associated systemic disease (PASD), is a metabolic disorder affecting sheep and goats during the later stages of gestation, particularly in animals carrying multiple fetuses. This study describes seven outbreaks of pregnancy toxemia in small ruminants in no...

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Autores principales: Sandoval, Gabriela Virginia, Martínez, Agustín, Felice, M., Homse , L., Colque Caro , Luis Adrián, Medina Vallejo, Diego, Avellaneda-Cáceres, Agustín, Aguirre Castro, Laura Sabrina, Micheloud, Juan Francisco
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Nordeste 2026
Materias:
metabolic disease
small ruminants
hepatic lipidosis
negative energy balance.
enfermedad metabólica
pequeños rumiantes
lipidosis hepática
balance energético negativo
Acceso en línea:https://revistas.unne.edu.ar/index.php/vet/article/view/9100
Aporte de:
Revistas UNNE - Universidad Nacional del Noroeste (UNNE) de Universidad Nacional del Nordeste
id I48-R154-article-9100
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spelling I48-R154-article-91002026-02-04T15:46:13Z Pregnancy toxemia in goats and sheep in Argentina: epidemiology, pathogenesis, and regional insights Toxemia de la preñez en cabras y ovejas en Argentina: epidemiología, patogénesis y particularidades regionales Sandoval, Gabriela Virginia Martínez, Agustín Felice, M. Homse , L. Colque Caro , Luis Adrián Medina Vallejo, Diego Avellaneda-Cáceres, Agustín Aguirre Castro, Laura Sabrina Micheloud, Juan Francisco metabolic disease small ruminants hepatic lipidosis negative energy balance. enfermedad metabólica pequeños rumiantes lipidosis hepática balance energético negativo Pregnancy toxemia, also known as pregnancy-associated systemic disease (PASD), is a metabolic disorder affecting sheep and goats during the later stages of gestation, particularly in animals carrying multiple fetuses. This study describes seven outbreaks of pregnancy toxemia in small ruminants in northwestern and southern Argentina, diagnosed at the Animal Health Laboratories of INTA Salta and INTA Bariloche. Morbidity rate ranged from 3% to 24%, and mortality reached up to 100% among affected animals. Necropsy and histopathological examinations revealed severe hepatic lipidosis, with up to 80% of the liver parenchyma affected. Elevated hepatic enzymes and the presence of urinary ketone bodies confirmed the diagnosis in two outbreaks. Goats exhibited more severe lesions and a poorer therapeutic response than sheep. The disease occurred under both adequate and deficient nutritional conditions, suggesting the influence of multiple predisposing factors. These findings underscore the importance of appropriate early nutritional management and preventive monitoring during late gestation, and provide new regional data that contribute to a better understanding of pregnancy toxemia in small ruminants. La toxemia de la preñez es un trastorno metabólico que afecta a ovejas y cabras durante las últimas etapas de la gestación, especialmente a aquellas que llevan múltiples fetos. Este artículo describe siete brotes de toxemia de la preñez en pequeños rumiantes del noroeste y sur de Argentina, diagnosticados en los Laboratorios de Salud Animal de INTA Salta y de INTA Bariloche. La tasa de morbilidad varió entre 3% y 24% y la mortalidad alcanzó hasta el 100% de los animales afectados. Los hallazgos de necropsia e histopatología revelaron lipidosis hepática severa con hasta un 80% de afectación del parénquima. La elevación de enzimas hepáticas y la presencia de cuerpos cetónicos en orina confirmaron el diagnóstico en algunos casos. Las cabras presentaron lesiones más graves y una respuesta terapéutica inferior que las ovejas. La enfermedad se presentó tanto en condiciones nutricionales adecuadas como deficientes, lo que sugiere la influencia de múltiples factores predisponentes. Estos resultados resaltan la importancia de un adecuado manejo nutricional temprano y un monitoreo preventivo durante la gestación avanzada y aportan nuevos datos regionales sobre la toxemia de la preñez en pequeños rumiantes. Universidad Nacional del Nordeste 2026-02-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/9100 10.30972/vet.3719100 Revista Veterinaria; Vol. 37 (2026); 1-5 Revista Veterinaria; Vol. 37 (2026); 1-5 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/9100/8816 Derechos de autor 2026 Gabriela Virginia Sandoval, Agustín Martínez, M. Felice, L. Homse , Luis Adrián Colque Caro , Diego Medina Vallejo, Agustín Avellaneda-Cáceres, Laura Sabrina Aguirre Castro, Juan Francisco Micheloud https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-154
container_title_str Revistas UNNE - Universidad Nacional del Noroeste (UNNE)
language Español
format Artículo revista
topic metabolic disease
small ruminants
hepatic lipidosis
negative energy balance.
enfermedad metabólica
pequeños rumiantes
lipidosis hepática
balance energético negativo
spellingShingle metabolic disease
small ruminants
hepatic lipidosis
negative energy balance.
enfermedad metabólica
pequeños rumiantes
lipidosis hepática
balance energético negativo
Sandoval, Gabriela Virginia
Martínez, Agustín
Felice, M.
Homse , L.
Colque Caro , Luis Adrián
Medina Vallejo, Diego
Avellaneda-Cáceres, Agustín
Aguirre Castro, Laura Sabrina
Micheloud, Juan Francisco
Pregnancy toxemia in goats and sheep in Argentina: epidemiology, pathogenesis, and regional insights
topic_facet metabolic disease
small ruminants
hepatic lipidosis
negative energy balance.
enfermedad metabólica
pequeños rumiantes
lipidosis hepática
balance energético negativo
author Sandoval, Gabriela Virginia
Martínez, Agustín
Felice, M.
Homse , L.
Colque Caro , Luis Adrián
Medina Vallejo, Diego
Avellaneda-Cáceres, Agustín
Aguirre Castro, Laura Sabrina
Micheloud, Juan Francisco
author_facet Sandoval, Gabriela Virginia
Martínez, Agustín
Felice, M.
Homse , L.
Colque Caro , Luis Adrián
Medina Vallejo, Diego
Avellaneda-Cáceres, Agustín
Aguirre Castro, Laura Sabrina
Micheloud, Juan Francisco
author_sort Sandoval, Gabriela Virginia
title Pregnancy toxemia in goats and sheep in Argentina: epidemiology, pathogenesis, and regional insights
title_short Pregnancy toxemia in goats and sheep in Argentina: epidemiology, pathogenesis, and regional insights
title_full Pregnancy toxemia in goats and sheep in Argentina: epidemiology, pathogenesis, and regional insights
title_fullStr Pregnancy toxemia in goats and sheep in Argentina: epidemiology, pathogenesis, and regional insights
title_full_unstemmed Pregnancy toxemia in goats and sheep in Argentina: epidemiology, pathogenesis, and regional insights
title_sort pregnancy toxemia in goats and sheep in argentina: epidemiology, pathogenesis, and regional insights
description Pregnancy toxemia, also known as pregnancy-associated systemic disease (PASD), is a metabolic disorder affecting sheep and goats during the later stages of gestation, particularly in animals carrying multiple fetuses. This study describes seven outbreaks of pregnancy toxemia in small ruminants in northwestern and southern Argentina, diagnosed at the Animal Health Laboratories of INTA Salta and INTA Bariloche. Morbidity rate ranged from 3% to 24%, and mortality reached up to 100% among affected animals. Necropsy and histopathological examinations revealed severe hepatic lipidosis, with up to 80% of the liver parenchyma affected. Elevated hepatic enzymes and the presence of urinary ketone bodies confirmed the diagnosis in two outbreaks. Goats exhibited more severe lesions and a poorer therapeutic response than sheep. The disease occurred under both adequate and deficient nutritional conditions, suggesting the influence of multiple predisposing factors. These findings underscore the importance of appropriate early nutritional management and preventive monitoring during late gestation, and provide new regional data that contribute to a better understanding of pregnancy toxemia in small ruminants.
publisher Universidad Nacional del Nordeste
publishDate 2026
url https://revistas.unne.edu.ar/index.php/vet/article/view/9100
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first_indexed 2026-02-17T05:00:46Z
last_indexed 2026-02-17T05:00:46Z
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