NSAID-induced nephrotoxicity: A case report

The use of human NSAID, such as ibuprofen, poses a critical risk in veterinary medicine due to their nephrotoxicity, frequently exacerbated by self-medication by pet owners. These drugs inhibit prostaglandins that regulate renal blood flow, causing severe damage, particularly at high doses or in deh...

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Autores principales: Condolo, Luis, Martínez Zambrano, Jaime Javier, Mancheno, Andrés, Rodríguez Arévalo, Andrés Francisco
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Nordeste 2026
Materias:
Acute kidney injury
ibuprofen
canine
therapy
diagnosis
lesión renal aguda
ibuprofeno
enfermedad canina
terapia
diagnóstico
Acceso en línea:https://revistas.unne.edu.ar/index.php/vet/article/view/9153
Aporte de:
Revistas UNNE - Universidad Nacional del Noroeste (UNNE) de Universidad Nacional del Nordeste
id I48-R154-article-9153
record_format ojs
spelling I48-R154-article-91532026-03-06T21:22:42Z NSAID-induced nephrotoxicity: A case report Nefrotoxicidad inducida por AINEs: Reporte de caso Condolo, Luis Martínez Zambrano, Jaime Javier Mancheno, Andrés Rodríguez Arévalo, Andrés Francisco Acute kidney injury ibuprofen canine therapy diagnosis lesión renal aguda ibuprofeno enfermedad canina terapia diagnóstico The use of human NSAID, such as ibuprofen, poses a critical risk in veterinary medicine due to their nephrotoxicity, frequently exacerbated by self-medication by pet owners. These drugs inhibit prostaglandins that regulate renal blood flow, causing severe damage, particularly at high doses or in dehydrated animals. This report presents the case of a 13-year-old male Golden Retriever that developed acute kidney injury (AKI) following ibuprofen administration, highlighting the importance of early diagnosis and appropriate clinical management. Treatment included fluid therapy and pharmacological agents aimed to alleviate clinical signs and restore renal function. It was concluded that, although the patient showed clinical improvement, NSAID-induced acute kidney injury in veterinary medicine requires continuous monitoring using specific biomarkers, which allows for early detection assessment of renal damage. La administración de antiinflamatorios no esteroideos (AINEs) de uso humano en animales de compañía representa un riesgo crítico en medicina veterinaria debido a su nefrotoxicidad, agravada frecuentemente por la automedicación por parte de los tutores. Estos fármacos inhiben las prostaglandinas que regulan el flujo sanguíneo renal, provocando daños severos, especialmente en dosis altas o animales deshidratados. En este reporte se describe el caso de un canino macho de raza Golden Retriever de 13 años que desarrolló lesión renal aguda (LRA) tras la administración de ibuprofeno, destacando así la importancia de un diagnóstico precoz y un manejo adecuado. El tratamiento consistió en fluidoterapia y productos farmacológicos para mitigar signos clínicos y restaurar la función renal. Se concluyó que, aunque el paciente presentó una mejora clínica, la lesión renal aguda inducida por AINEs en veterinaria requiere una monitorización constante mediante el uso de biomarcadores específicos, lo que permite una detección temprana del daño renal. Universidad Nacional del Nordeste 2026-03-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/xml application/epub+zip https://revistas.unne.edu.ar/index.php/vet/article/view/9153 10.30972/vet.3719153 Revista Veterinaria; Vol. 37 (2026); 1-6 Revista Veterinaria; Vol. 37 (2026); 1-6 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/9153/8990 https://revistas.unne.edu.ar/index.php/vet/article/view/9153/9009 https://revistas.unne.edu.ar/index.php/vet/article/view/9153/9010 Derechos de autor 2026 Luis Condolo, Jaime Javier Martínez Zambrano, Andrés Mancheno, Andrés Francisco Rodríguez Arévalo https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-154
container_title_str Revistas UNNE - Universidad Nacional del Noroeste (UNNE)
language Español
format Artículo revista
topic Acute kidney injury
ibuprofen
canine
therapy
diagnosis
lesión renal aguda
ibuprofeno
enfermedad canina
terapia
diagnóstico
spellingShingle Acute kidney injury
ibuprofen
canine
therapy
diagnosis
lesión renal aguda
ibuprofeno
enfermedad canina
terapia
diagnóstico
Condolo, Luis
Martínez Zambrano, Jaime Javier
Mancheno, Andrés
Rodríguez Arévalo, Andrés Francisco
NSAID-induced nephrotoxicity: A case report
topic_facet Acute kidney injury
ibuprofen
canine
therapy
diagnosis
lesión renal aguda
ibuprofeno
enfermedad canina
terapia
diagnóstico
author Condolo, Luis
Martínez Zambrano, Jaime Javier
Mancheno, Andrés
Rodríguez Arévalo, Andrés Francisco
author_facet Condolo, Luis
Martínez Zambrano, Jaime Javier
Mancheno, Andrés
Rodríguez Arévalo, Andrés Francisco
author_sort Condolo, Luis
title NSAID-induced nephrotoxicity: A case report
title_short NSAID-induced nephrotoxicity: A case report
title_full NSAID-induced nephrotoxicity: A case report
title_fullStr NSAID-induced nephrotoxicity: A case report
title_full_unstemmed NSAID-induced nephrotoxicity: A case report
title_sort nsaid-induced nephrotoxicity: a case report
description The use of human NSAID, such as ibuprofen, poses a critical risk in veterinary medicine due to their nephrotoxicity, frequently exacerbated by self-medication by pet owners. These drugs inhibit prostaglandins that regulate renal blood flow, causing severe damage, particularly at high doses or in dehydrated animals. This report presents the case of a 13-year-old male Golden Retriever that developed acute kidney injury (AKI) following ibuprofen administration, highlighting the importance of early diagnosis and appropriate clinical management. Treatment included fluid therapy and pharmacological agents aimed to alleviate clinical signs and restore renal function. It was concluded that, although the patient showed clinical improvement, NSAID-induced acute kidney injury in veterinary medicine requires continuous monitoring using specific biomarkers, which allows for early detection assessment of renal damage.
publisher Universidad Nacional del Nordeste
publishDate 2026
url https://revistas.unne.edu.ar/index.php/vet/article/view/9153
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AT condololuis nefrotoxicidadinducidaporainesreportedecaso
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first_indexed 2026-03-17T05:00:57Z
last_indexed 2026-03-17T05:00:57Z
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