Sterol analogues with diamide side chains interfere with the intracellular localization of viral glycoproteins

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The need to develop novel antiviral agents encouraged us to assess the antiviral activity of synthetic sterol analogues with a diamide side chains. Cytotoxicity and antiviral activity of a family of azasterol previously synthesized was evaluated against herpes simplex virus 1 (HSV-1) (KOS and B2006)...

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Autores principales:	Cabrera, Gabriela Myriam, Ramirez, Javier Alberto, Barquero, Andrea Alejandra
Publicado:	2012
Materias:	Antiviral Azasterol Glycoprotein transport HSV-1 Ugi reaction VSV azacosterol diamide glycoprotein D n [(tert butylcarbamoyl)methyl] n (2 chlorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (2 ethyl 6 methylphenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (2 fluorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (3 trifluorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (3,4 dichlorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (4 fluorophenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (4 methoxyphenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide n [(tert butylcarbamoyl)methyl] n (4 methylphenyl) 3beta hydroxyandrost 5 ene 17beta carboxamide unclassified drug virus glycoprotein animal cell antiviral activity article chemical reaction drug synthesis fluorescence analysis Herpes simplex virus 1 nonhuman priority journal protein localization virogenesis virus inhibition Antiviral Agents Diamide Herpesvirus 1, Human Humans Intracellular Space Sterols Viral Envelope Proteins Virus Replication Human herpesvirus 1 Vesicular stomatitis virus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v427_n1_p107_Davola http://hdl.handle.net/20.500.12110/paper_0006291X_v427_n1_p107_Davola
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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